The clinical syndromes associated with Mycoplasma bovis infection in cattle including respiratory disease, arthritis, otitis, meningitis, reproductive disease and keratoconjunctivitis are well known and reported in the literature. Reports in the literature and feedback from the field would suggest that the incidence of these disease syndromes is increasing and that treatment and management can be challenging. This presentation will highlight the different disease syndromes seen, their diagnosis, management and prevention. Case examples of the different clinical disease manifestations will be presented, including information on potential risk factors. In particular lessons learned from these varied case presentations will be discussed to help inform practitioners with scenarios encountered in their own client’s herds.